UC Davis Well being is happy to announce that the Chair of Bodily Medication and Rehabilitation Craig McDonald and his staff can be honored with a 2023 High Ten Scientific Analysis Achievement Award. The award is offered by the Scientific Analysis Discussion board. It’s in recognition of McDonald’s exceptional work creating a stem cell remedy to deal with probably the most extreme sufferers with Duchenne muscular dystrophy (DMD). The uncommon genetic dysfunction causes muscle loss and bodily impairment in younger individuals and results in untimely demise.

McDonald is the nationwide principal investigator main HOPE-2, a multicenter double-blind randomized trial.

“We’re honored to obtain this prestigious award for our work on a promising novel remedy for sufferers with late-stage DMD,” mentioned McDonald, professor of pediatrics and bodily drugs and rehabilitation. “Our scientific trial HOPE-2 confirmed important and unprecedented stabilization of skeletal muscle deterioration within the arms and cardiomyopathy affecting the guts in DMD sufferers who’re unable to stroll.”

HOPE-2 is a collaboration with Capricor Therapeutics and the Smidt Coronary heart Institute at Cedars-Sinai Medical Heart, the place pre-clinical work on the cell remedy was carried out.

Choice standards for the High 10 Scientific Analysis Achievement Award

The High Ten Scientific Analysis Achievement Award honors groundbreaking achievements in scientific analysis from throughout the U.S. A Scientific Analysis Discussion board panel selects the High 10 award recipients from scientific analysis research revealed in peer-reviewed journals in 2022. The choice is predicated on:

  • the diploma of innovation and novelty concerned within the development of science,
  • contribution to the understanding of human illness or physiology
  • potential affect upon the analysis, prevention or therapy of illness

McDonald’s award-winning paper on the HOPE-2 trial was revealed in The Lancet.

Scientific analysis that brings hope to DMD sufferers

a middle-aged doctor with short whitish-gray hair, wearing eyeglasses and a white coat
Chair of Bodily Medication and Rehabilitation Craig McDonald

UC Davis Well being Vice Dean for Analysis Kim E. Barrett nominated McDonald for this award.

“We have been delighted to appoint Dr. McDonald for this recognition and so happy to study of his choice as a High 10 Scientific Analysis awardee,” mentioned Barrett, distinguished professor of physiology and membrane biology at UC Davis. “His work has essential implications for treating sufferers with Duchenne muscular dystrophy and is a superb instance of the caliber of analysis carried out at UC Davis Well being.”

The intravenous cell-based remedy makes use of cardiosphere-derived cells. It represents an thrilling and modern strategy to stabilizing higher limb and coronary heart perform for sufferers with probably the most extreme DMD. Because it addresses the later levels of the illness, it will possibly tremendously affect the standard of life for boys and younger males with DMD and reduce the burden of care for his or her households.

“I want to thank Dr. Barrett for the nomination and acknowledge my companions at UC Davis and the various different establishments that collaborated on this groundbreaking scientific trial,” McDonald mentioned. “Particular thanks go to the sufferers and their households, my co-authors on this research, and the incredible groups within the Division of Bodily Medication and Rehabilitation Neuromuscular Analysis Program and the UC Davis Alpha Stem Cell Clinic.  We additionally acquired necessary help from Dad or mum Challenge Muscular Dystrophy, a number one advocacy group for DMD sufferers and households.”

Concerning the Scientific Analysis Discussion board and the High 10 Scientific Analysis Award

The Scientific Analysis Discussion board promotes understanding and help for scientific analysis and its affect on well being and healthcare.

“The High 10 Scientific Analysis Achievement Awards honor and have fun the innovation, tireless efforts and profound contributions that scientific researchers and advocates have made on the well being and wellness of humanity,” mentioned Harry P. Selker, chair of the Scientific Analysis Discussion board and dean of Tufts Scientific and Translational Science Institute at Tufts College. “We congratulate the 2023 winners for his or her excellent efforts.”

This yr’s High 10 Awards can be held on April 17 in Washington, D.C.

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